Hyperpolarized [1-13C]-acetate Renal Metabolic Clearance Rate Mapping
نویسندگان
چکیده
منابع مشابه
Investigation of metabolic changes in STZ-induced diabetic rats with hyperpolarized [1-13C]acetate
In the metabolism of acetate several enzymes are involved, which play an important role in free fatty acid oxidation. Fatty acid metabolism is altered in diabetes patients and therefore acetate might serve as a marker for pathological changes in the fuel selection of cells, as these changes occur in diabetes patients. Acetylcarnitine is a metabolic product of acetate, which enables its transpor...
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Within the last decade hyperpolarized [1-13C] pyruvate chemical-shift imaging has demonstrated impressive potential for metabolic MR imaging for a wide range of applications in oncology, cardiology, and neurology. In this work, a highly efficient pulse sequence is described for time-resolved, multislice chemical shift imaging of the injected substrate and obtained downstream metabolites. Using ...
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PURPOSE Our aim was to determine the quantitative reproducibility of metabolic breakdown products in the kidney following intravenous injection of hyperpolarized [1-(13)C]pyruvate and secondly to investigate the metabolic effect on the pyruvate metabolism of oral sucrose load using dissolution dynamic nuclear polarization. By this technique, metabolic alterations in several different metabolic ...
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Background 13C Dynamic Nuclear Polarization (DNP) with rapid dissolution together with Magnetic Resonance Chemical Shift Imaging (CSI) have been used for non-invasive real-time metabolic assessment in cardiac experimental models on a clinical 3T scanner. Here, we report an in vivo comparison of hyperpolarized [1-13C] pyruvate and [1-13C] acetate perfusion and metabolism: a method based on a 3D ...
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In order to compare in vivo metabolism between malignant gliomas and normal brain, (13)C magnetic resonance (MR) spectroscopic imaging data were acquired from rats with human glioblastoma xenografts (U-251 MG and U-87 MG) and normal rats, following injection of hyperpolarized [1-(13)C]-pyruvate. The median signal-to-noise ratio (SNR) of lactate, pyruvate, and total observed carbon-13 resonances...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-15929-x